Cellular Energy Medicine

Recharge your cells.
Reclaim your energy.

NAD+ therapy replenishes your body's most essential coenzyme — addressing fatigue, brain fog, and metabolic slowdown at the cellular level.

IV & IM Injection Options Physician-Supervised In-Clinic & Telehealth MN & WI
500+
Metabolic
Processes Supported
50%
NAD+ Decline
by Age 50
86%
Report Improved
Energy After Series
4–6
Sessions for
Cellular Renewal
What Is NAD+

The coenzyme your cells cannot function without.

Nicotinamide Adenine Dinucleotide (NAD+) is found in every living cell. It drives the reactions inside your mitochondria that convert food into ATP — the fuel your cells run on. Without adequate NAD+, mitochondria become less efficient and the effects ripple through everything: energy, metabolism, cognition, and cellular repair.

Beyond energy, NAD+ activates sirtuins — proteins that regulate DNA repair, inflammation, and cellular stress. These are the same pathways researchers link to healthy aging. NAD+ is also required for PARP enzymes that repair DNA strand breaks, which happens constantly in every cell.

500+
Enzymatic Reactions
NAD+ participates in over 500 metabolic reactions throughout the body
50%
Decline by Age 50
Levels drop ~50% between your 30s and 50s, accelerated by stress and poor sleep
3
Sirtuin Families Activated
SIRT1, SIRT3, SIRT5 — regulate aging, metabolism, and cellular health
DNA Breaks Repaired Daily
PARP enzymes require NAD+ to repair thousands of DNA strand breaks per cell per day
How NAD+ Powers Every Cell
Food You Eat
Carbohydrates, fats, and proteins enter metabolic pathways
NAD+ Accepts Electrons
Becomes NADH — the electron carrier that enters the ETC
Critical step
Mitochondria (ETC)
Electron transport chain uses NADH to drive ATP synthesis
ATP Production
Usable cellular energy — powers every function in every cell

Depleted NAD+ breaks this chain. Less efficient electron transport = less ATP = less energy for every cell — which is why low NAD+ affects everything from physical stamina to cognitive clarity.

The Decline Problem

Your NAD+ is falling right now.

NAD+ decline with age is one of the most well-documented phenomena in cellular biology — observed across species and multiple human tissues including skin, liver, and brain. But it doesn't decline evenly. Lifestyle factors dramatically accelerate the drop.

What drives faster decline
Chronic stress (elevates CD38, which consumes NAD+)
Alcohol consumption
Chronic sleep deprivation
DNA damage (activates PARP, consuming NAD+)
Obesity and metabolic syndrome
Regular exercise (slows decline)
Sources: Massudi et al. 2012 (skin), Zhu et al. 2015 (brain), Camacho-Pereira et al. 2016 (Cell Metabolism). Age-related NAD+ decline observed across human tissues and multiple model organisms.
Relative NAD+ Levels by Decade — Human Tissues Based on published tissue studies
Low 100% 75% 50% 25%
100%
Age 20s · Peak NAD+ levels
20s30s40s50s60s70s+
Normal age-related decline
Accelerated (stress/alcohol/poor sleep)
High-risk zone (below 30%)
Self-Assessment

Recognize the signs of NAD+ depletion.

Check any symptoms you're currently experiencing. Your results will show your depletion likelihood and the most appropriate Livea protocol.

Persistent fatigue
Tired even after 7–9 hrs sleep
Brain fog
Difficulty thinking clearly or focusing
Slow metabolism
Weight loss plateau or sluggishness
Muscle fatigue
Reduced exercise capacity or recovery
Mood changes
Increased irritability or low motivation
Poor sleep quality
Trouble falling asleep or staying asleep
Age 40+
NAD+ decline accelerates significantly after 40
High stress lifestyle
Chronic stress elevates CD38, consuming NAD+
Alcohol consumption
Regular drinking depletes NAD+ reserves
On weight loss program
Caloric restriction increases NAD+ demand
Your NAD+ Depletion Score
0
/ 27 pts
Select your symptoms above
Check the boxes that apply to you and see your personalized NAD+ depletion assessment.
Delivery Methods

Why delivery method matters for results.

NAD+ must reach your cells to work. The route of administration determines how much actually gets there — and how fast. Here's the science on each option.

Maximum Dose
IV Infusion
Direct bloodstream delivery · 2–4 hour session
Relative Bioavailability
~97%
  • Bypasses digestion entirely — direct bloodstream delivery
  • Highest possible therapeutic concentration
  • Fastest cellular saturation — ideal for intensive reset
  • Physician-monitored throughout the session
  • Recommended for burnout recovery, first intensive series
Most Popular
IM Injection
Intramuscular · 10–15 minute visit
Relative Bioavailability
~85%
  • Bypasses first-pass metabolism in the gut
  • Quick 10–15 minute in-office visit
  • Ideal for weekly or bi-weekly maintenance
  • Most cost-effective ongoing option
  • Physician-prescribed dosing protocol
Oral Supplements
NMN / NR Pills
Precursors · Requires conversion · OTC supplements
Relative Bioavailability
~10–25%
  • Must survive stomach acid and intestinal enzymes
  • Requires conversion to NAD+ inside cells
  • High individual variability in conversion efficiency
  • No physician oversight or dosing precision
  • Human trial results inconsistent (small sample sizes)
Conceptual Absorption Curve — NAD+ Blood Concentration Over Time by Delivery Method
Illustrative representation based on pharmacokinetic principles for IV, IM, and oral routes. Oral figures reflect NMN precursor conversion variability.
High Mid Low 0h 2h 4h 8h 12h 24h
IV Infusion (direct bloodstream)
IM Injection (muscle tissue)
Oral supplement (variable conversion)
Weight Loss Connection

Why NAD+ is a game-changer for weight loss.

Cellular energy is the foundation of everything. When NAD+ is depleted, your mitochondria can't produce energy efficiently — and that inefficiency shows up as fatigue, reduced exercise motivation, metabolic slowdown, and cravings that make dietary discipline nearly impossible.

  • More energy for movement. Restored mitochondrial function directly improves physical energy, making it easier to stay active.
  • Improved metabolic efficiency. NAD+ activates SIRT1 and AMPK — regulators of fat oxidation and insulin sensitivity.
  • Reduced fatigue-driven overeating. Fatigue is one of the most common triggers for poor food choices. Higher NAD+ helps stabilize energy and reduce cravings.
+47%
Mitochondrial Function
Improvement in obese subjects with NAD+ precursor supplementation (Cell Metabolism)
SIRT1
Fat Metabolism Activated
NAD+ activates SIRT1, which regulates fat burning and insulin sensitivity
AMPK
Cellular Energy Sensor
NAD+ activates AMPK, which promotes fat burning during caloric restriction
Better Outcomes Combined
Patients combining NAD+ with structured weight loss report improved energy and adherence
NAD+ + GLP-1 Protocol Synergy
GLP-1 Medication (Semaglutide / Tirzepatide)
Reduces appetite and caloric intake
Improves glucose control
Reduces food noise
+
NAD+ Therapy (IV or IM)
Restores mitochondrial energy production
Activates fat metabolism pathways
Reduces caloric-restriction fatigue
Comprehensive metabolic support
More energy · Better adherence · Enhanced fat oxidation
NAD+ therapy at Livea
Cellular Energy Medicine

Your cells deserve better fuel.

NAD+ is the most fundamental molecule in cellular energy production. When it declines, everything declines with it.

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The Science

What the research actually tells us.

NAD+ has become one of the most studied molecules in longevity and metabolic research. We present the evidence across 5 domains with honest strength ratings — including where research is compelling and where more human data is still needed.

Energy & Metabolism
Mitochondrial Function
Evidence Strength
Strong — Multiple human trials
NAD+ activates SIRT1/SIRT3 sirtuins and AMPK, which regulate mitochondrial biogenesis and fat oxidation. Human studies show measurable improvements in mitochondrial efficiency and metabolic rate with NAD+ restoration in overweight adults.
Key studies: Yoshino et al., Cell Metabolism (2011) · Canto et al., Cell (2012) · Pencina et al., J Clin Endocrinol Metab (2023, N=50+ overweight adults)
Cognitive Function
Brain Energy & Clarity
Evidence Strength
Moderate — Strong mechanistic, early clinical
NAD+ supports neuronal energy production and activates SIRT1 in the brain, reducing neuroinflammation. Clinical observations consistently report improvements in mental clarity and focus following NAD+ restoration. Larger controlled trials still needed.
Key sources: Buck Institute for Research on Aging · Hou et al., Neuron (2021) · Neuroprotective pathways well-established; large-scale RCTs ongoing
DNA Repair
PARP-Mediated Repair
Evidence Strength
Very Strong — Mechanistic certainty
PARP1 enzymes — which repair thousands of DNA strand breaks daily — require NAD+ as substrate. This is mechanistically well-established. When NAD+ is depleted, PARP activity is compromised, accumulating DNA damage. This is not theoretical.
Key sources: Fang et al., Cell Metabolism (2016) · PARP1 NAD+ dependency is foundational biochemistry — documented extensively since the 1970s
Physical Performance
Exercise Capacity & Recovery
Evidence Strength
Moderate — Positive human trial signals
NMN supplementation (600–1200mg) increased aerobic capacity in amateur runners (Liao 2021). A 2024 RCT in older adults showed significantly faster 4-m walking speed and improved sleep quality vs placebo after 12 weeks. Individual variability is significant.
Key studies: Liao et al. (2021, amateur runners, N=48) · Igarashi et al., GeroScience (2024, RCT, N=60 older adults)
Cellular Aging
Longevity & Sirtuin Activation
Evidence Strength
Promising — Strong preclinical, early human
Dr. David Sinclair (Harvard) has published extensively on NAD+ as a key regulator of aging through sirtuin activity. Animal studies show reversal of cellular aging markers with NAD+ restoration. Human longevity trials are still underway — mechanistic evidence is compelling.
Key sources: Sinclair lab, Harvard Medical School · Cell (2013, mouse studies) · Multiple ongoing Phase II human trials as of 2024–2025
Cardiovascular Health
Vascular Function & Lipids
Evidence Strength
Emerging — Early positive signals
A 2023 12-week RCT showed NMN significantly reduced arterial stiffness, LDL cholesterol, and diastolic blood pressure in middle-aged adults. The NMN group had reduced pulse wave velocity suggesting improved vascular health. Sample sizes remain small.
Key study: Katayoshi et al. (2023, double-blind RCT, N=36, middle-aged adults) — reduced vascular stiffness and LDL with 250mg NMN/day for 12 weeks

An honest note on the evidence: Most human trials of NAD+ precursors involve small sample sizes (14–100 participants) and short durations (8–12 weeks). Direct IV/IM NAD+ has fewer formal clinical trials than oral precursors, though the pharmacokinetic case for superior bioavailability is well-established. Livea's position: the mechanistic evidence is strong, patient outcomes are consistently positive in our clinical experience, and the safety profile is excellent. We present these results to patients with appropriate nuance.

Treatment Options

Two ways to restore your NAD+ levels.

Whether you want a quick in-office visit or a higher-dose intensive session, both options are delivered under full physician supervision at Livea. Your provider will help you choose the right approach.

IV
Intensive Support
NAD+ IV Infusion
Direct bloodstream delivery · Maximum bioavailability · Fastest cellular saturation
  • 2–4 hour in-clinic session
  • Maximum dose and ~97% bioavailability
  • Fastest cellular saturation — ideal for intensive reset
  • For burnout recovery, first series, or accelerated results
  • Physician-monitored throughout the infusion
IM
Most Common
NAD+ IM Injection
Quick in-office delivery · ~85% bioavailability · Ideal for maintenance
  • Quick 10–15 minute in-office visit
  • Weekly or bi-weekly scheduling
  • Most affordable ongoing option
  • Ideal for maintenance after initial IV series
  • Physician-prescribed dosing protocol
Treatment Planner

Build your personalized protocol.

Select your goals and preferences to see a recommended session plan, timeline, and what to expect. All protocols confirmed by a Livea physician at your free consultation.

Primary goal
Preferred delivery method
How often can you come in?
Your Recommended Protocol
All protocols are customized by a Livea physician at your free consultation. Pricing discussed individually — typically HSA/FSA eligible — check with your provider to learn more.
Book Free Consultation to Confirm →
What's Included

Everything for a fully supported NAD+ experience.

01
Initial Consultation & Lab Panel
Health history review and baseline assessment to determine your NAD+ protocol and confirm eligibility.
02
Physician-Prescribed Dosing Protocol
Custom treatment plan tailored to your health status, goals, and delivery method preference.
03
In-Clinic Administration
All injections and infusions performed by trained clinical staff at your Livea location.
04
Ongoing Monitoring & Check-ins
Regular assessment of your response, energy levels, and protocol adjustments as needed.
05
Integration with Weight Loss Program
Seamless coordination with your GLP-1, Medical Weight Loss, or HRT program if applicable.
06
Flexible Scheduling
Appointments at 8 MN & WI clinic locations with convenient scheduling options.
Is This Right for You?

Find out if NAD+ therapy fits your situation.

NAD+ therapy is appropriate for a wide range of adults experiencing energy decline, metabolic challenges, or cognitive changes. A brief consultation will confirm whether it's right for your specific health status.

Good Candidates
  • Adults age 35+ experiencing unexplained fatigue or declining energy despite adequate sleep
  • People experiencing brain fog, difficulty concentrating, or mental sluggishness
  • Those on a weight loss plateau or looking to enhance metabolic function
  • Currently enrolled in Livea GLP-1 or Medical program and wanting enhanced results
  • Adults with reduced exercise tolerance limiting activity
  • Individuals interested in longevity and cellular health support
Precautions & Considerations
  • Active cancer treatment — discuss with your oncologist and Livea medical director before proceeding
  • Certain liver conditions that affect processing of high-dose nutritional compounds
  • Pregnancy or breastfeeding — insufficient safety data currently available
  • Known hypersensitivity to NAD+ or related niacin-based compounds

A provider consultation will confirm whether NAD+ therapy is safe and appropriate. Livea's medical team takes a conservative, safety-first approach to all treatments.

Patient Stories

Real experiences from Livea NAD+ patients.

★★★★★
More energy
than my 30s
"I was exhausted all the time and just assumed it was part of getting older. After my fourth NAD+ session I felt genuinely energized for the first time in years. My workouts improved, my mood lifted, and the weight started moving again."
Mark S.
NAD+ IV Infusion + Medical Weight Loss
★★★★★
Brain fog
cleared
"The brain fog I was dealing with made everything harder — work, parenting, staying on track with my diet. NAD+ cleared that fog within a few weeks. I finally feel sharp and motivated again. My injections only take a few minutes."
Jennifer K.
NAD+ Injections, improved clarity and focus
★★★★★
29 lbs lost +
GLP-1 synergy
"I was skeptical at first, but combining NAD+ with my GLP-1 prescription made a huge difference. I have more energy, fewer side effects, and my metabolism finally feels like it is working with me. I've lost 29 pounds."
Patricia L.
NAD+ + GLP-1 combination program
Active lifestyle with NAD+ therapy
Live Without Limits

Feel the difference real energy makes.

Our members don't just feel better — they move better, think clearer, and live fuller.

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N+
Free Consultation

Find out if NAD+ therapy is right for you.

No obligation. No pressure. Just an honest conversation with a Livea provider about your health goals.

  • Free initial consultation
  • In-person or telehealth available
  • IM injections from 10 minutes
  • Typically HSA/FSA eligible
  • Serving all of MN & WI
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FAQ

Common questions about NAD+ therapy.

NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme present in every cell. It is essential for converting food into energy (ATP), repairing DNA, regulating gene expression, and activating sirtuins that protect cells from aging and stress. NAD+ levels decline by roughly 50% between your 30s and 60s, contributing to fatigue, brain fog, slow metabolism, and reduced cellular repair. Supplementing via injection or IV restores these levels, supporting energy, cognition, and metabolic efficiency.
Livea offers two delivery methods: intramuscular (IM) injection and IV infusion. IM injections are quick in-office procedures — similar to a standard shot — and are ideal for regular, convenient treatment. IV infusions deliver NAD+ directly into the bloodstream over approximately 2–4 hours, allowing for higher doses and faster cellular uptake. Both are administered at Livea clinics under physician supervision.
Most patients begin with an initial series of 4–10 sessions over a few weeks to build NAD+ levels to a therapeutic threshold. After completing the initial series, most clients transition to a maintenance schedule of weekly, bi-weekly, or monthly sessions depending on their response. Your provider will customize the frequency and adjust it over time based on how you feel and what you are trying to achieve.
IM injections are quick and generally well-tolerated. IV infusions may cause mild temporary sensations such as warmth, tingling, or mild nausea during the infusion, which is why the infusion rate is carefully controlled. After treatment, many patients report a noticeable boost in energy and mental sharpness within hours. Over a series of sessions, patients commonly notice improved sleep quality, mood, stamina, and focus.
Many patients notice an initial increase in energy and mental clarity within 24–48 hours of their first session. More sustained improvements — better sleep, improved mood, enhanced exercise performance, and sharper thinking — typically become more pronounced after completing the initial series of 4–6 treatments. Results vary based on individual NAD+ deficiency levels, age, and overall health status.
NAD+ therapy is generally considered an elective wellness treatment and is not typically covered by standard health insurance. It is an out-of-pocket expense. Livea provides transparent pricing during your initial consultation. Livea is typically HSA/FSA eligible — check with your provider to learn more. Your care team will walk you through all costs before you commit to any treatment.
Yes — combining NAD+ therapy with GLP-1 medications is one of the most effective approaches for comprehensive metabolic support. NAD+ improves mitochondrial function and cellular energy production, which enhances the metabolic benefits of GLP-1 therapy. Many patients find that NAD+ reduces the fatigue that sometimes accompanies GLP-1 use or caloric restriction, making it easier to stay active.
Oral NAD+ supplements (such as NMN or NR) must survive digestion and conversion before reaching the bloodstream — a process that significantly limits bioavailability to roughly 10–25%. Intravenous and intramuscular NAD+ bypasses the digestive system entirely, delivering the coenzyme at approximately 85–97% bioavailability. This results in much higher and more reliable therapeutic concentrations, which is why injections and IV infusions produce noticeably faster and more consistent results than oral supplementation.
Get Started

Ready to restore your energy from the inside out?

Book a consultation with a Livea provider and find out how NAD+ therapy can support your energy, metabolism, and weight loss goals. No obligation.

Serving all of Minnesota and Wisconsin